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If the address matches an existing you will receive an with instructions to retrieve your username. Ronald O. Mice derived entirely from embryonic stem ES cells can be generated through tetraploid complementation. Although XY male ES cell lines are commonly used in this system, occasionally, monosomic XO female mice are produced through spontaneous Y chromosome loss. The monosomic XO female mice are viable and able to produce normal male and female offspring. Direct generation of clonal mice in both sexes can ificantly accelerate the production of complex genetically modified mouse models.

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Forgot your username? Yiren Qin Ronald O. Search for more papers by this author. Bokey Wong Ronald O. Liangwen Zhong Ronald O. Luis F. View article. Figures References Related Details.

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